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Bioethik
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»Leben machen« und »sterben lassen« Grundlagen, Themen und Probleme der BioethikSterbehilfe, Abtreibung, Stammzellenforschung – die Bioethik beschäftigt sich mit hoch brisanten Themen, die in Politik und Öffentlichkeit heftig diskutiert werden. In seiner Einführung ste [...] |
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Body Composition Assessment in Children and Adolescents
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During growth and development of children, body composition, predominantly fat and lean body mass, plays a central role. The body composition parameters are important determinants of child health, also in regard to obesity. This volume is a collection of articles presenting a broad scope o [...] |
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Human CD38 and Related Molecules
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In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+-mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell si [...] |
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Catalytic Antibodies
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Catalytic antibodies have attracted attention because they can combine exquisite specificity with permanent and potent antigen inactivation. The field has enjoyed a renaissance in recent years due to the discovery of antibodies with comparatively efficient peptidase and nuclease activities [...] |
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Genes and Genetics of Autoimmunity
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Autoimmunity is one of the most highly investigated areas of immunologic research. The principle of immune system discrimination between self and foreign molecules is fundamental to the survival of the species, and the failure to establish or maintain this discrimination can lead to a wide [...] |
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Pharmacokinetics of Selected Antibacterial Agents
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During the early years of antibiotic research, there was little interest in the pharmacokinetic properties of antibacterial agents. However, the past decades have seen a tremendous progress in pharmacokinetic analysis which has made it necessary to reevaluate the pharmacokinetics of some o [...] |
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Low-Calorie Sweeteners, Present and Future
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The field of artificial sweeteners is a complex one: each sweetener is unique in terms of its composition and taste, and those allowed by legislation vary according to country. Furthermore, they exist certain controversial issues, i.e. are sweeteners really useful in weight management or a [...] |
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Complement in Autoimmunity
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Complement protein expression and activation control central aspects of the normal B cell response. Imbalances in these processes invariably lead to autoimmune disease. Complement activation causes tissue damage in a number of ways and may by itself lead to autoimmune disease. Although the [...] |
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Vertebrate Sex Chromosomes
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During the last two decades of the 20th century, the study of chromosomes was enormously stimulated by the availability of various biological resources, valuable databases and new genetic and molecular biological techniques including PCR and fluorescent in situ hybridization. The simultane [...] |
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B Cell Biology in Autoimmunity
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B cells play a central role not only in adaptive immunity, but also in autoimmunity. The aim of this book is to understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it. This volume includes more than a do [...] |
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